When choosing area for running mission(s):
- 0.5 System will give highest ISK/LP per mission in rewards (in HS). - as you mentioned
- Min 4-5 jumps to nearest Low/Null sec system, to avoid getting sent there.
- Choose the best type of Mission to suit you goals:
- Security missions if you want best ISK/H using an appropriate BS and fit.
- Distribution missions if all you want is to get your standing up with the Corp. I can recommend Heron and Nereus for the job.
- Mining missions are pretty much useless.