I typically go for all the cans. B-line straight for the next gate while I fight popping the caches as I come in. When I get 2.5k from the gate drop an MTU and finish the fight. Usually by the time I’m done fighting almost all the loot is pulled in and I have a brief moment to recover cap and shields. That said I do the sites for industry materials and loot, not pure profit.
My personal philosophy is every cache you don’t snag is one less roll for a specialization book or faction turret.