Graphics Slowdown in Jita 4 4

I’ve been using the optimised settings fine with a 2880x1620 resolution, most options on or set to high, without issue tbh. However I went to Jita 4 4 yesterday and it literally dicks and hangs.
Weird thing is, sometimes it works, and sometimes it fails.
In the end I managed to get in using low settings, but the same resolution.

So understand if the Graphics Card is being overloaded, but struggling to work out in my head why sometimes, and not all the time etc.

My only option was to kill the client (when possible) to restart and attempt again. The issue that was frustrating, is that once you are docked, its hard to load the game, and get to the settings to amend, before it hangs again!

So wondering if there is a way to access the graphics settings from outside the game, so they are pre amended before I relaunch (e.g. safe mode start)?

Hardware:
iMac (Retina 5K, 27-inch, 2019)
Processor 3.6 GHz 8-Core Intel Core i9
Memory 32 GB 2667 MHz DDR4
Graphics Radeon Pro Vega 48 8 GB