My hauler alt flies T1 industrials, makes regular runs through Forge, Lonetrek, Citadel and Sinq Laison, and has only been hi-sec ganked once – in Josameto.
That gank happened to be the only time I was ever autopiloting with any significant cargo. Coincidence? I think not.
So first thing: don’t autopilot with gank-worthy stuff in your hold. Ever.
IMO your biggest risk is on station undock, so the insta-undock bookmark is crucial if you’re leaving a trade hub with valuable stuff. If you’re empty, no worries.
Second biggest risk is on station dock, so instadock bookmark is helpful, too.
Third biggest risk is at gates. Learn the Afterburner/warp trick if you’re flying a slow-aligning ship like a Tayra – ensures your maximum align time is about 8 seconds.
That said, I hauled for months before learning those tricks, and it wasn’t a big deal. I tended to leave the hub empty and return full, so insta-undock didn’t matter. And I’ve never been ganked on hub approach, even when the game drops me 1500m from the station. I just hit the afterburner and reached the station in a few seconds.
Also, remember that gankers can suffer from information overload at a hub like Jita. I’ve sometimes moved extremely valuable cargo in a Merlin, because who is going to bother cargo-scanning a Merlin amid dozens of other ships? Could happen, but usually they’ll scan the bigger fish first. Shuttles seem to be an exception: I guess people routinely move enough valuable stuff in shuttles that they get special attention.
In terms of fit, it depends on what you’re doing. My “regular” hauling ship is a small, fast tanked T1 freighter with some inertial stabs. It has enough cargo space to handle 90% of my hauling needs, enough tank to take a few volleys, and aligns in 6.5 seconds.
I also have a larger T1 fitted for max cargo. They say “never fit for max cargo”, but all I ever use it for is hauling bulk items like Tritanium and structure modules that would be tedious or impossible to haul in my main ship. It’s just not a gankworthy target.
I fly through Uedama regularly. Yes, it’s occasionally filled with gankers. But I’ve never been bothered. Hell, I flew my regular routes during Burn Jita this year, and the only problem I had was lag. I think they look at my boring little freighter and think “too small to bother with.”
Or else I’m the luckiest pilot in space.