I am now using blasters in lvl 4 mission and I got to say they are a “blast”, but what NPC group gives a blaster fit the most problems, I know Guristas do with all that jamming, and probably blood raiders I could see nueting you out and tracking sensor blocks, as far as that what has been troublesome for you using blasters.
I am using T-1 blasters Antimatter/Iron mostly.
Using a vindicator T-2 fit.
Look out for nuets for sure. Missile ships will usally be the ones keeping range on ya. If you know your are going into a heavy missile fight I would have a rail gun setup handy or it can turn into a lot of chasing.
Sometimes vs omni damage it will be a pain to have sufficient tank to stay that close. If you dont want to bling out your ship then you may want to also use a range setup for facing omni damage.