Low Sec already has lots of this. Low sec is where most pithum and gisthum a-type loot comes from (you can get it in null by farming the lwo end anomalies that generate 6/10 DEDs, but not many people do this as its so hit or miss)
And you can’t get Pithum/Gisthum B or C type at all in null. Low Sec is almost the sole supplier. Pithum B Type invuls are selling for half a bil right now in jita, there are few null sec sourced deadspace items that will get you that much.
Then there is the loot from Clone NPCs in low sec belts that you can’t get anywhere else. And while not exclusive to low sec, FW missions and level 5 missions spew LP amounts that can’t be matched anywhere, giving low sec mission runners an edge in producing high value items from those stores.
Low sec’s problem is not rewards. Since 2009 CCP has added reward after reward after reward (including unique rewards, see pithum/gisthum b/c type loot) and yet it doesn’t really help. The issue is that Low Sec is just painful to play in for a lot of reasons, some of which aren’t that obvious.
Adding more rewards to low sec just enriches the few big low sec alliances (and null sec alt groups) that immediately seize the space where the rewarda are produced. This is why you see low sec alliances creating a stranglehold on the systems where lvl 5 mission agents are present.