the big alliances take the space to rent it out there by making passive isk generation for the alliance.
i have been in null sec many times and you can go a good number of jumps not seeing people because no corp has been moved into that area.
you cant go out and just take some of that own space because you wouldnt get very far in attacking a goon system or some other large alliance that either holds that space or rents it out despite no one ever using that system for operations
Thatās the point, it may seem empty but just try to take one of those āemptyā systems for your own and you will find out how empty it really isnāt when you get hot dropped.
In the place of colony ships, Iād say introducing hulls capable of generating self-wormholes (i.e. only one for itself, read the Inheritance chronicle) would make a nice starting point for this idea - making cynos unusable in new space would also necessitate the building up of resources within a claimed system to the point where a group could construct the necessary infrastructure to make a stargate, with which they could connect back to regular space.
As a base, Iād assume Jove Directorate and (Antiquated-recovered) Talocan ships to be the first ones able to use wormhole navigation. From there, Supercarriers and Titans could be somehow allowed to be fitted with one (Sanshaās Nation, despite having wormhole tech, has only managed to squeeze it onto a Supercarrier at smallest).
And for anyone with some reservations about this sort of thing, New Spaceā¢ was always at the end of CCP Seagullās roadmap to the future, with many additions weāve seen in recent years acting as stepping stones along that path. Since her departure, Iāve really felt that weāve lost this sort of direction in development - many disparate features that donāt appear to have an end-goal seem to have superseded or delayed some of the things Seagull always talked about - but I still hope the planās moving in the background.