I’m using the Debian Testing distribution with WINE 3.2 aka “wine-development” as described here. None of the winetricks are necessary.
If it wasn’t for the “Windows XP”-mode setting needed to get it to work then you could say that the EVE Online Windows client runs “out of the box” on WINE.
I still enable DX9 in the launcher over DX11 for more FPS, and unless one enables anti-aliasing does it also run with DX11 as far as I’ve seen. I also set the environment variable WINEDEBUG to “-all” to turn off all the debugging channels in WINE for some more FPS, and I already mentioned how to get rid of screen tearing, which can occur in combination with some of the window compositors here. However, none of these are show stoppers.