SOE Epic Arc & Povchen systems?

Are there any problems running the SOE arc now due to having to travel through Povchen systems?

You should not need to run through any Pochven because they are cut off systems from the rest of the cluster. They did not create any unreachable islands. The only issues you could encounter are Minor Victory systems infested with Trigs and generally Trigs appearing in a number of systems within 3 jumps around MVs.