Yes it does.
Normal mode for missions brings the majority of your ISK from pay, bonuses and bounties. Blitz brings the majority of the ISK from buying things with the LP you gain and then selling them on the markets.
Standard ammo across all types has the worst stats. It’s primary advantage is it is cheap to buy, if you make your own it is even cheaper.
Faction ammo. Better than T1 and in some cases and for some weapons systems better than T2 but it is the most expensive to buy. That cost can be reduced to some degree by buying or making T1 and then converting it to faction at a loyalty points store.
T2 ammo is in a general sense the best across all weapons types and for most situations. It is less expensive to buy then faction but making it yourself may not be any cheaper than buying it.
So the real question is which is better for you and your specific needs and for that no one can answer the question but you. Experiment with the options and see what works best for you.
Personally and for PvE I always use T2 in a missile ship, usually use T2 for laser and always use faction for projectile or hybrid weapons.