There is no way that an alpha ship even with the best alpha fitting, can defeat any of the good fitted ships currently in null sec(mostly omega ships there). There is also nothing useful to do in null sec for an alpha. Minerals that only appear in null sec can be ice mined, degassed, or mined by omega, as the source object itself is omega. Most of the alpha rocks in null sec can be found in low sec. Anti-warp bubbles are mostly Omega, so trapping ships is not possible for an alpha in null sec. The PvE in null sec is too hard for an average alpha user.
Places that are low or high sec that are only accessible via null sec should get a way to get accessed via low sec, if null sec becomes omega only.
For this reason, Known Space null sec should become Omega only.