‘Safe’ is relative. Even high sec is not safe with active players around, so no newly created system that is in between high and low sec will ever be safe either, unless it’s more safe than high sec.
Then maybe find some low sec systems that are less traveled? I don’t live in low sec, but usually when I pass through low sec it’s really empty. Might be related that I pass through low sec systems from null sec side, rather than on the high sec gate.
Null sec on the other hand is much more lively (and dangerous!) than most low sec systems I’ve been in. But again, I might be biased because I’m living in a rather active part of null sec that sees a lot of roaming hostiles.
It widely varies how dangerous null sec or low sec is based on the players that are around. And it will be a lot safer to travel in null sec that is under control by your allies, while hostile null sec space with bubble camps can be a lot more dangerous. But even those can be navigated if you know how.
So yes, our experiences do not correlate. So based on experience alone we cannot objectively tell whether null sec or low sec is more dangerous.
However, based on ingame rules we can. Any PvP that is allowed in low sec is allowed in null sec, but low sec has a few protective measures that make it safer to travel through: no bombs allowed and no bubbles allowed. So, according to the game rules low sec is safer to travel through than null sec.
While technically people can catch 2s align ships, I’ve only been caught by such a camp once by taking a highly traveled pipe in high sec with war targets around. If you stay away from the most common routes people likely won’t waste time and resources to set up a camp like that.
Also, they can set up such a camp anywhere, including null sec, or like my experience: high sec. So this danger isn’t unique to low sec.
Second, I don’t know what new players start with, but you only need Evasive Maneuvering level 2 combined with Spaceship Command level 1 to have a shuttle align within 2s.
If they don’t get those levels by default, then they can train it in a few minutes.
Super safe travels through low sec are therefore accessible to newbies too, at least once they figure out how to use their d-scan and bounce from celestials after they’ve been smartbombed the first time.