if properly setup the scrollwheel/natural touch will behave just like on windows on 2dimentional objects.
such as
hangar windows, markets mails … (anything that has a scrollbar really)
but when inteacting with 3d space like space itself, eg. panning and zooming using the wheel, or zooming your ship while in a Station, or just resizing the probe scanner view … the controls are inverted.
which is extremly distracting if one uses a mac and a windows computer with shared input.