You can rat in nullsec in a dread, but it is risky and inefficient due to having to go in 5 minute siege cycles. Wormhole PvE is where dreads shine. You can use them solo in C5s and in a group in C6s, pretty much in any site in these classes of wormholes. When you warp capitals to wormhole anomalies they spawn additional NPCs for extra loot as well.
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