The pure numbers you get from losses are not as accurate for high sec as they are for null simply due to the amount of ganking that happens in space. For a well executed gank each real kill also nets 2 other losess one for the concord loss and one for concord manipulation loss. Now often a single ship is not enough to gank a single target so you may end up losting 20 ships to kill one targert (10 + 10 losess) and then possibly some pods if you are not that good. And then there are the failed gank attempts. So even when high sec might look dangerous it has pretty much 40% extra buffer on the statistics page.
And then there are the PVE missions and new players starting new accounts and dying at their first sites and quitting the game. So a lot of extra kills in this area as well.
Now high sec is dangerous if you do not know what you are doing. Same applies to other regions. When you know what you are doing the risk of losing your ships is greatly reduced. Most often people who do not know what they are doing are the new players who either haul too much value in their T1 ships or mine in hulks in 0.5 systems. Each time you add too much bling you also increase the risk. New players sadly do this without knowing about the risk factor as the word high sec gives them a faulty feeling of security.
You can make a lot of money in high sec when you are in the right ship and know what you are doing. Just like in null sec. Due to this i think there should be some risk in high sec as well otherwise everyone would just stick farming in high sec. For me high sec is a place where you can chill a bit more and not care about mandatory sov stratops or structure farms and enjoy doing what you personally like to do.
The risk is not the problem, its the education and getting new and old players connected with other eve players. If they are not connected they most likely keep on doing the same mistakes over and over again and do not know where to seek help. This can be very hard for a new player. Once players learn that high sec is not a secure space they will start to pay attention to other details such as their fits or travel routes etc. Once this is done the risk vs. knowledge balances out the risk vs. reward.
So to put it all together for a fresh new player the risk vs. reward is rather high in HS. However once they learn to operate and know more about the game the risk element balances out with the rewards and as long as you operate by taking other players around you into account you can hammer out pretty high isk.