To try to be a bit more helpful…
I do not know the economics of your situation, so my comments must be interpreted in light of that.
My JF route is from JITA area and 4 jumps (35k light years) into null. Since the cyno changes, I’ve made about 20 round trips and lost about 8 Nereus’s. Each Nereus only ever has a single industrial cyno and ozone on-board. The first set, I bought at around 1M isk and others I built at-cost.
Of those I’ve lost, some were in low and some in null.
I am using a fixed route and I had no problems manually flying in the first set and even going out to get a few replacements before I dropped off a couple at each location on my next JF run.
I use the MWD method to get them into low, and add the “watch intel” method when first moving them into null. My economics are such that if I lost a cyno + ship on every trip, I’d still be doing okay. I realize that might not be the case for everyone. Over the lifespan of my JF (haven’t lost one yet), I expect it to pay for itself in the costs saved by not needing to hire it out to a hauling service. Since you’ve already made the substantial investment in a JF, I think you’ll be able to sort out the economics and methods in a way that will work for you.
Even with a large network of stations/structures to service, I assert it is possible to set it up in a sustainable way. I do not assert that it is necessarily easy, nor that a new JF pilot ought to have considered all the things one might need to do to establish a viable JF business.