No. Very no. Cycle time matters, versatility matters, and tech level matters.
Also very no. Asymmestric layouts have literally no benefits other than with asymmetrical use, like heating one neut over another. If I had one medium neut and one small, I would do G/G/M/G/S/G.
3–1 is almost as bad as 4–. The middle guns will get way too much heat, as will the inner neut. If you only heat neuts, they will burn each other out just as fast as with 2–2 or 4–, but they will damage the surrounding guns way more than in the 4-- config. It turns out to be exponentially worse than -4-, and even worse than 1-2-1, due to the neuts burning each other out quicker. Of course, -4- is the best option for permaheating the neuts and only the neuts, but no one does that. 2–2 is best for heating only guns.
The only scenario where I think 3–1 is even a possibility is when that one is a much faster cycling different module, like a dual 180mm autocannon on a HAM ship, which doesn’t meaningfully exist in the game. In addition, you’d have to only overheat the periphery one for a while with the express intent of heating all your 3s later, and want to minimize heat to them beforehand.
If you only heat guns, the middle one in slot 3 will burn out quicker than any of them would in either 1-2-1 or 2–2, meaning less overheat time, as the stack burns out with the gun. If you only heat the neuts, guns 3 and 6 will have a lot of damage on them, but not 1 and 2, leading to wasted heat potential in those two guns by the time 3 burns out.
If you are doing them both heated, number 3 will burn out exceedingly fast, and your ship will lose a ton of overheat value.
Another thing I’d like to point out, is that putting offline stuff in the highs is not good for heat.
It takes just as much damage as online stuff, and the heated stuff still takes the same amount of damage.
Heat damage in partially calculated using the percent of total slots you have fitted. In other words, empty slots actually make your ship take less damage (but not necessarily run cooler per se) than if they were filled with offline “heat sinking” modules.
Another point. Always keep the prop mod at the edge, unless it’s an MJD, in which case put it in the middle.
ABs but especially MWDs put out a lot of heat, and they can burn ouot mids really fast if you’re not careful. Add that to the huge damage per cycle of a prop mod and you can burn out your tackle or Multispec at an incredibly fast rate. Once the Prop(s) are on the edges, I like to put scrams/points as far away as possible and then nestle offline stuff right next to the prop.
AB, Shield Extender, web, web, scram is the safest configuration. If one of the webs is T2 and the other is T1, or if one is more valuable in some way, I’d put it closer to the AB, just because if I am heating web I am most likely heating scram too.
Some people say to put props in between stuff, like going SE, AB, SE, other stuff, but that is very bad. Not necessarily bad for the SEs, but the other stuff is going to take a lot of unnecessary damage. On a ship with a prop, 2x SEs, and three tackle mods (say 2x web + point), I do the mids in exactly that order.
ASBs are tricky, but I usually put them in the same place as the extender, because they aren’t (hopefully) going to suffer much heat damage on their own.
Armor reps are easy. Just put the reps on the outside, (using a dual rep example) with the RAH or active hardener smack dab in the middle, or closer to the ancillary rep if you have one.
If you only have one rep, put whatever next to it. I usually do speed stuff, then armor stuff, then damage, then DCU, but I get lazy. I have been known to even run DCU, SAAR, damage on frigs.
Examples:
AR, damage, DCU, Reactive, multispec, AAR
AAR, DCU, multispec, damage, AR
AAR, overdrive, damage, DCU
AR, damage, hardener (tertiary), damage, hardener (secondary), DCU, hardener (weakness)
Shield Boosts are a pain. Midslots are very different in use so organizing them can be difficult.
On my frigates, I do:
AB, web, cap booster, booster, scram
…or a variation.
When it comes to larger ships, I have no idea, because the largest shield boosts I use are mediums, and those are super rare for me. I’d guess…
Booster, MJD, grapple, boost amp, scram/point, multispec
…but I have no idea.