Here’s my criteria for what would make up the perfect system or string of systems for doing lots of Abyssal Deadspace:
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Security status is 0.5, or just above depending on the tiers you’re running, so that you can avoid the suspect status flag after doing runs.
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NPC buy orders for red loot in the staging system or very nearby to the staging system.
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Close proximity to a trade hub for convenience and whatever else you are doing.
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Cheap jump clones so that you are paying less to switch.
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Good support for other optional activities (mining, exploration, low sec systems).
After looking around today, I found a place that has all of these things. The line from Hai in Domain (0.5 security) goes through a 0.6, then a 0.7 (Mamenkhanar). Mamenkhanar has NPC buy orders for Triglavian Surveys and a public Athanor that is selling jump clones for 95k ISK. Amarr is only 3 jumps away from Mamenkhanar, so you can make it to a trade hub easily. There’s also a public refinery with a good tax rate for mining and some nearby low sec systems for shenanigans and exploration. Customs offices in the nearby low-sec systems have a pretty standard 10% tax rate.
If you’re wondering why I’m posting this, it’s because I think it would be nice to get more Abyss runners into the same area. Abyss is set up to support group activities, yet aside from multi-boxers there doesn’t seem to be a lot of actual groups doing Abyss content, which I think is a shame. But if we could get more people into the same system or chain of systems (people who do higher tiers could base out of the nearby 0.5 system, then sell their red loot in the 0.7 on the way to Amarr) I think it might provide the foundation for more group Abyssal Deadspace running.
Edit: Some people have suggested to me that suicide gankers might camp such a system to attack Abyss runners. I personally don’t think this would be viable long term because they’d be trying to suicide gank people who are always in combat ships for likely lower profit margins than what other forms of suicide ganking can offer.