Mouse gets locked in place on Mac Big Sur

I just got this issue on my Mac but I am not sure which Alt key combo triggered it - I think it was Alt-V which I have mapped as my Cmd-V for Paste and seems to conflict with an EVE keybinding for opening the Activity Tracker, but found this old post and Alt+R fixed it, but how do I prevent it from happening again? I don’t have any Radeon driver overlay programs like this guy talked about, that I know of:

iMac (Retina 5K, 27-inch, Late 2015)
AMD Radeon R9 M395X 4 GB
Big Sur 11.01

In OS 11 I have alt mapped as my cmd key and windows key mapped as alt so not sure why EVE is not respecting that either …