I am by no means an expert, but I have done this twice and gotten more or less what I wanted from it. This would have been Great Wildlands from 2018-2020 and Pure Blind from 2020-2023. I am a super casual soloist who dabbles in most things and excels in nothing.
First thing to understand is living in peace solo is somewhat of a contradiction in NPC null. Most of the time, you’re prey. Some days that’s okay, some days that’s a roadblock. In GW, I focused on manufacturing for other locals. I kept destroyers and cruisers stocked, plus their mods, and made some mining and hauling ships as well. Did okay, eventually won back my investment. Talking to people, advertising your contracts, this might win you some leeway when you’re out mining/huffing. But they also have their own Indy people so you’re still competition. Everyone is hostile until proven neutral. No one is blue.
This brings me to the second point: you have a very limited number of stations to base from, depending on what services you plan on using. This means it will be easy to determine where your home is located and what you tend to do there. If a bloc decides you’re a gnat they want to swat, not much you’re going to be able to do about it other than send tributes or try to timezone-tank their animosity. Something to consider when planning.
I would start with a DST. It will be highly advantageous to get Transport Ships to V since you’ll want every bonus you can get. The ship hangar is useful and you can pack a great deal in a single trip. CovOps, Expedition Frigate, BR, and a BC can all be fit in there, with all modules and ammo. Everything you need to explore, mine, and shunt your loot back to a market with as much safety as possible. So here’s point three: remember EVE rule number one and don’t fly this if you can’t afford to lose it.
Join the Signal Cartel public channel in-game. Use the Thera and Turnur shared bookmarks folder, but bear in mind everyone else has those bookmarks. Don’t advertise or telegraph what you’re doing. Then wait for a connection through Thera to your desired NPC region with an entry that is not anywhere near a major tradehub. The shorter the route for you between that entrance and your prospective base, the better your chances. Once you’re in null, never travel gate-to-gate. Always bounce off celestials to create your tacticals, and approach gates from an oblique if possible. If you make it, congrats, you’re now staged.
At this point, you may want to consider using public JF services to bring a care package of starter equipment to your new home. Could be anything pertinent to the content you enjoy. This is just an option if you have the funds and inclination.
Greybill blog has a good guide on bookmark hygiene, as well as a few for solo fits for null. Research the null belt/ratting fits that suit you, and see if you can build those for yourself, though it may be a while and you may need to rely on outside sources for supplies you don’t have immediate access to. If you can, integrate into the local economy and market. If it helps generate content for others, you’ll be a welcome part of the ecosystem. Good luck and have fun.