When the quietness of W-space is its only safety feature, it doesn’t say very much.
Secondly, if your citadel is attacked, you lose everything. There is no asset safety.
Gatecamps can be a problem but you can avoid 80% of them through the http://eve-gatecheck.space/eve/ site.
And I haven’t even mentioned locked down space in 0.0.
0.0 and Lowsec – just dock up any time something comes into local. Actually impossible to die unless you’re stupid enough to be in siege mode.