There is going to be your problem.
The closest thing to “safe space” in Eve is high sec. Depending on who you ask, HS not all that safe either.
The mechanics make it hard for small groups to take and hold null sec space, but I think it’s possible. It has to be fought for though. Anything worth having will have to be defended.
Wormholes are easier and harder at the same time. A small active group (15+ people) can hold a lower class hole (C3 or smaller) against anything aside from a serious eviction.
Lots of money to be made in WH’s but you wont make it mining rocks.
As a counter-point to this post, here are some arguments for why you shouldn’t base in NPC stations and daytrip in wormholes, and why anchoring a structure in wormhole space can be better:
Having a structure in wormhole space means you can run industry jobs with your own taxes and indices+you can configure structures to your taste.
Wormhole PI can be quite lucrative and you miss out on it if you don’t have a permanent base/access to untaxed POCOs.
Basing out of a wormhole allows you to reroll connections conveniently (takes 5 minutes per wormhole with 2 characters), to find better holes for logistics, krabbing or PVP. This can make it a lot safer and more reliably lucrative than relying on hisec WH connections (which could be crawling with third parties).
Despite the Siege Green structure nerf, wormhole structures are still very affordable for anything that can be called a ‘group’ or ‘corp’, so the risk of getting bashed someday generally doesn’t outweigh the rewards you’ll make with convenient access to w-space.