With the margins on items a 1% me difference is a large difference in profit. So it’s still a pretty significant thing.
I know this is an area we disagree on though is where structure advantages lie. I’d rather see the me type bonuses identical in all areas of space. Then sov gives things like system index is easier to keep low, no default tax etc, fuel discounts. Which do save money but a smart and busy person could find an out of the way highsec system and balance their production well to turn a competitive profit.
Nulls advantage should be in its rich resources. Which hopefully this change to moons helps with. Not a multiplicative effect on also having better facilities.