Hello friend … i strongly suggest you to focus on this post carefully . YES, YOU CAN AVOID LOSSES AGAINST EMPIRE FACTIONS PERFECTLY … ALSO IF YOUR CHOICE IS PIRATE FACTIONS ALSO WORKS FINE .
This is what you going to do.
1 -Decide about the most important faction that you don’t want to lose standing… if you don’t want to gain negative standing against guristas and gallente … i would say cladari missions not really ideal for you…
2- You need to find a station with two lvl 4 agents ! from same corporation and same faction you grinding… There is just you need to be bit more clever to fiddle with ingame agents search tool and use some advanced search parameters.
3- whenever one of those agents gives you a mission check mission’s name from this list!
In that list you can see all the missions names and in case you accept the mission you will see what kind of burden you will take over… and just refuse the missions against for example all empire factions .
that way you wont loose so much standing and never loose freedom of travel in EVE Online …
If one agent gives you mission against empire factions… just refuse it then roll for the next agent… most of the time they give different missions while one of them on cooldown without costing you any standing loss against that agent … you do the other one…
though time by time … they may give both missions against the same faction for example… then take a breake after cool down refuse this one and get the new mission from other agent… you can juggle around that way… or you can roll for SOE mission agents ( NOT epic arc ! ) LP store stuff is profitable…
Also you can consider some factions mainly settle down in null areas if you never consider to go and settle down with that toon in null sec… lol… i have messed up with one of Pirate Faction once soo badly with one of my alt but doent care because i never see them in space and never got shot by them due to her area of interaction and interest.
Mission running not even my special i do PVP… but if you have any question feel free to reach out to me ingame
Hope this post helps you little bit and hope its answer your question o/
And also if anyone have some extra information please add … i cant remember how many minute you need to wait was it 15 min ? Before you refuse offered mission without penalty ? Or 30 min ?