short run: influx of players that want to avoid interaction and go run missions and level up their raven with crazy shiny fits. A bunch of hulks show up in belts.
mid run: most of those short term players quit because leveling up your raven is boring. Trade hub shenanigans as players run 100b+ freighters around risk free.
years out: ???
long run: heat death of the universe, eve actually dies.
obviously nothing changes in null because according to them highsec is irrelevant, something something build more titans.
Other effects:
People will load up haulers and freighters to insane levels.
Every man and his dog will haul, leaving the professionals to have to concentrate on low/null routes.
Officer fit ships will become more common as long as the supply of modules hold up.
Hi sec income will be nerfed hard.
P.S, I realise points 3 and 4 are rather contradictory longterm.
Are you sure that PvE, predictable content, leads to demand which surpasses local production? PvE is straight forward and easily minmaxable, especially when everyone does it.