Gaining high standings with Thukker Tribe will be tough and take a long time to achieve without incurring substantial loss with all the other Empire Factions.
I’ve thought a lot about how to gain positive standing with all Factions and have come to the realization that a couple of Factions just can’t be done at this time. First to start with, players will need to build up a very large amount of standing with the main Empire Factions to act as a buffer.
With the help of Pirate Epic Arcs and Cosmos Agents, positive standings can then be gained with most of the Pirate Factions. With a very large amount of Empire Faction standings to act as a buffer, Thukker, Sansha, Angel, Guristas and The Syndicate can all be raised to positive standing. Course players will definitely have to keep watch on Concord Faction to make sure it doesn’t drop to -5.00 or lower standing. Then players can still safely travel through Concord controlled high security systems.
Some older players already have positive standings with Concord so completing all of the Pirate Cosmos Agents and Pirate Epic Arcs should help preserve access to Concord controlled high sec systems. So that leaves Serpentis and Blood Raiders. I believe trying to gain positive standings with those Factions will definitely tank Concord standings.
In reality, only the High Sec Factions really matter, all the other Factions just need to stay above -2.00 standing for access to high level agents via Corp Standing.